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Niko Papanikolaou

From Radiological Sciences

Contents 1 Biographical Sketch – Niko Papanikolaou, Ph.D., FACMP, FAAPM 1.1 Academic Appointments: 1.2 Role in Graduate Program: 1.3 Committees: 1.4 Course Instructor: 1.5 Faculty Advisor: 1.6 Graduates Supervised: 1.7 Students Supervising: 1.8 Education: 1.9 Continuing Education: 1.10 Certification: 1.11 Clinical Responsibilities: 1.12 Research Interests: 1.13 Inter and Extra-mural Support: 1.14 Teaching: (past 3 years) 1.15 Selected Publications:

[edit] Biographical Sketch – Niko Papanikolaou, Ph.D., FACMP, FAAPM

[edit] Academic Appointments:

Professor of UTHSCSA, Departments of Radiation Oncology and Radiology

[edit] Role in Graduate Program:

Core Faculty

[edit] Committees:

• Member, COGS
• Chair, Therapy Physics Curriculum Committee,
• Member, Qualifying Examination Committee
• Member, Application Review Committee

[edit] Course Instructor:

Yes

[edit] Faculty Advisor:

Yes

[edit] Graduates Supervised:

Lan Lin

[edit] Students Supervising:

Vikren Sarkar, Fan-Chi (Frances) Su, Jun Xu, Tricia Tynan, Chellie Ramer, Teboh Roland, Drosoula Giantsoudi, Yaxi Liu

[edit] Education:

• University of Wisconsin – Madison Ph.D 1994-Medical Physics
• University of Wisconsin – Madison M.S. 1991-Medical Physics
• University of Athens – Greece B.S. 1989- Physics honors

[edit] Continuing Education:

AAPM, ESTRO, ASTRO, ACMP

[edit] Certification:

• Certified - American Board of Radiology in Therapeutic Physics
• Radiation Expert - State of Kentucky
• Licensed Medical physicists in the State of Texas
• University of Kentucky Certificate 1998-HealthCare Mgmt
• Univ of Pittsburgh Gamma Knife School Certified 2001-Gamma Knife User

[edit] Clinical Responsibilities:

• CTRC, Director of Medical Physics and Radiation Therapy
• Therapeutic Radiology-3D Treatment Planning and virtual simulation, *Multi-modality based treatment planning (CT-PET-MRI fusion), IMRT planning and delivery, HiArt TomoTherapy, Prostate implants, Intraoperative Radiotherapy, Linac Based Stereotactic Radiosurgery, Gamma knife, HDR and LDR Brachytherapy, Endovascular Brachytherapy, Dosimetry, Quality Assurance, Radiation Protection and Shielding design.
• Diagnostic Radiology-Routine QA on all types of imaging equipment, including radiographic, fluoroscopic, CT, mammography, cardiac catheterization, ultrasound, etc,,
• Nuclear Medicine
• Radiation Protection and Shielding design

[edit] Research Interests:

• Tomotherapy and Image Guided Radiotherapy
• Intensity Modulated Radiotherapy
• Radiobiological plan evaluation and modelling

[edit] Inter and Extra-mural Support:

• 2006 – 2007 Norman Endowment Grant
• 2006 – 2007 PI: Target tracking delivery using a dual bank micro MLC. Initia Corporation, $55,000
• 2006 – 2007 PI: IGRT implementation using the Peacock delivery system. NOMOS Corporation, $115,000
• 2006 – 2007 Co-investigator: Development of a Monte Carlo based 4D simulation toolikit. Cancer Care Council of San Antonio, $15,000
• 2004 – 2005 Co-investigator: Monte Carlo Algorithms and QA tools for Tomotherapy. Tomotherapy Inc, $120,000
• 2002-present Principal Investigator: IMRT teaching grant. Philips Medical Systems - $500,000. Develop an IMRT training course for the Pinnacle IMRT users as well as to investigate the application of biological optimization for IMRT
• 2003-2005 Co-investigator: PortSimTM A software platform for MLC field outline verification.
• $30,000 per year Comprehensive software package that will enable the projection of static and dynamic multi-leaf collimated (MLC) shaped beams on top of radiographic and fluoroscopic (RF) images for beam aperture and isocenter verification prior to treatment.
• 1996-1998 Principal Supervisor: Dr. Mildred Scheel Stiftung für Krebsforschung - $48,000 Research on dose calculation using convolution/superposition algorithms.
• 1999-2000 Principal Investigator: A clinical study for the commission of a convolution based algorithm for 3D RTP, ADAC Laboratories - $11,000.
• 1998-1999 Co-investigator: Microscopic computer-aided 3D reconstruction of prostate cancer.
• Veterans Affairs research type II proposal - $24,000.

[edit] Teaching: (past 3 years)

• University of Texas and Cancer Therapy & Research Center (2005-present)
• Medical Residency Program in Radiation Oncology
• Graduate Program in Medical Physics – Supervision of doctoral thesis of graduate students
• Medical Dosimetry Certificate Program - Contribute to teaching and supervision of students

[edit] Selected Publications:

1. Papanikolaou N, Mackie TR, Wells C, Gehring M, Reckwerdt P. “Investigation of the convolution method for polyenergetic spectra,” Med. Phys., 20(5), pp. 1327-1336, 1993.
   
2. Meger-Wells CM, Mackie TR, Papanikolaou N, Frye DMD, “Dosimetry of Stereotactic Radiosurgery Beams Using a Plastic Scintillation Detector,” Med. Phys., 20(3), 1993.
   
3. Meger-Wells CM, Mackie TR, Podgorsak MB, Holmes M, Papanikolaou N, Reckwerdt P, Cygler J, Rogers DWO, Bielajew AF, Schmidt D, Muehlenkamp J, “Measurements of the electron dose distribution near inhomogeneities using a plastic scintillation detector,” Int. Journ. Rad. Onc. Biol. Phys, 29(5), p. 1157, 1993.
   
4. Papanikolaou N, Mackie TR. "The extended phantom concept: modeling the treatment machine modifiers and portal imaging dosimetry system using a convolution code,” Med. Phys., 21(6), p. 877, 1994.
   
5. Papanikolaou N, Paliwal B. “A study of the effect of cone shielding in intraoperative radiotherapy,” Med. Phys., 22(5), pp. 571-575, 1995.
   
6. Papanikolaou N, Mackie TR, Gehring M, Fairbanks J. “Clinical implementation of a convolution based algorithm for 3D treatment planning,” Int. Journ. Rad. Onc. Biol. Phys., 32, Supplement 1, p. 302, 1995.
   
7. McNutt T, Mackie TR, Reckwerdt P, Papanikolaou N, Paliwal B. “Calculation of portal dose using the convolution/ superposition method,” Med. Phys., 23(4), pp. 527-535, 1996.
   
8. Papanikolaou N, Gehring M. “A study of the algorithm dimensionality in the calculation of dose for photon beam.” Med. Phys., 25(7), 1998.
   
9. Papanikolaou N, Klein E, Heudenn WR (moderator). “Heterogeneity corrections should be used in treatment planning for lung cancer” Point-counterpoint in Med.Phys. 27(9), pp.1702-1704, 2000.
   
10. Papanikolaou N, Strottmann JM, Cassola SL, Mohiuddin M, Regine WF. “Multi-modality guided treatment for brain tumors based on image fusion.” Radiology, v.217 Supplement, p. 158, November 2000.
    
11. Butker E, Ting J, Papanikolaou N, Davis L. “A time-motion study of a typical IMRT with inverse plannning and delivery.” Radiology, 217(Supplement) p. 202, November 2000.
    
12. Holmes L, Godette K, Papanikolaou N, Iwinski A, Ghavidel S, Ting J. “Using IMRT for management of cervix cancer.” Radiology, 217(Supplement), p. 315, November 2000.
    
13. Ting J, Butker E, Papanikolaou N, Iwinski A. “Radiation room shielding design with consideration of IMRT,” Radiology v.217 Supplement, p. 158, November 2000.
    
14. Papanikolaou N, Stathakis S, Tsougos Y, Kappas C. “The effect of tissue inhomogeneities in IMRT,” Med. Phys. 28(6), p. 1207, 2001.
    
15. Papanikolaou N. “Dose calculation algorithms in the IMRT era.” Radiotherapy and Oncology, 61(S1), p. 512, October 2001.
    
16. Papanikolaou N, Yan Y, Peñagarícano J, and Ratanatharathorn V. “Application of IMRT for the treatment of medulloblastoma,” Medical Physics, 29(6), p. 1215, June 2002.
    
17. Yan Y, Papanikolaou N, Peñagarícano J, and Ratanatharathorn V. “Automated patient positioning verification using orthogonal DRR and portal images,” Medical Physics, 29(6), p.1244, June 2002.
    
18. Papanikolaou N, Yan Y, Peñagarícano J, and Ratanatharathorn V. “The Impact of Daily Patient Set-up error and Tissue Inhomogeneities in PTV Coverage and OAR Avoidance Using IMRT”, Medical Physics, Vol. 29(6), p. 1286, June 2002.
    
19. Papanikolaou N, Peñagarícano J, Yan Y and Ratanatharathorn V. “A feasibility study of IMRT for cranio-spinal Irradiation,” Radiotherapy and Oncology, Vol. 64(Sup1), p.292, Sept. 2002.
    
20. Peñagarícano J, Papanikolaou N. “Intensity Modulated Radiation Therapy for Carcinoma of the Head and Neck,” Current Oncology Reports, 5(2) pp.131-139, March, 2003.
    
21. Elshihabi S, Ratanatharathorn V, Yan Y, Papanikolaou N, Peñagarícano J, Linskey M. “Current Principles for the Management of Solid Central Nervous Metastases,” Contemporary Neurosurgery, Vol 25(4), pp. 1-10, 2003.
    
22. Reft C, Alecu R, Das IJ, Gerbi BJ, Keall P, Lief E, Mijnheer BJ, Papanikolaou N, Sibata C, Van Dyk J. "Dosimetric considerations for patients with HIP prostheses undergoing pelvic irradiation,” Report of the AAPM Radiation Therapy Committee Task Group 63" Medical Physics, Vol. 30 (6) pp. 1162-1182, 2003
    
23. Papanikolaou N. “Algorithms for treatment planning with Photon Beams,” Med Phys, Vol. 30 (6) p. 1411, 2003.
    
24. Papanikolaou N, Penagaricano J, Yan Y, Youssef E, Wu C, Ratanatharathorn V. “Hi-Art Tomotherapy vs MLC based IMRT: plan dosimetry comparison,” Radiotherapy and Oncology, 68 (S42), 2004.
    
25. Penagaricano J, Papanikolaou N, Yan Y, Ratanatharathorn V. “Application of Intensity Modulated Radiation Therapy in Pediatric Malignancies.” Medical Dosimetry, 29(4), pp. 247-253, 2004.
    
26. Penagaricano J, Ratanatharathorn V, Papanikolaou N, Yan Y. “Intensity-Modulated Radiation Therapy reduces the dose to normal tissue in T2N0M0 squamous cell carcinoma of the glottic larynx.” Medical Dosimetry, 29(4), pp. 254-257, 2004.
    
27. Yan Y, Papanikolaou N, Weng, X, Penagaricano J, Ratanatharathorn V “Fast radiographic film calibration procedure for helical tomotherapy intensity modulated radiation therapy dose verification” Med Phys. 2005 Jun;32(6):1566-70.
    
28. Penagaricano J, Papanikolaou N, Wu, C, Yan Y. “An assessment of biologically-based optimization (BORT) in the IMRT era.” Medical Dosimetry 30 (1) pp. 12-19, 2005.
    
29. C Wu, CY Shi, C Yang, N Papanikolaou, V Ratanatharathorn, J A Purdy,S Vijaykumar, A Comparison between BAT and Tomotherapy MVCT on inter-fractional prostate localization. Medical Physics, 32(6), 2005
    
30. C.Y. Shi, N Papanikolaou, Y Yan, X Weng, An Analytic Approach to Film Based Absolute Dosimetry for IMRT. Medical Physics, 32(6), 2005
    
31. N Papanikolaou, CY Shi, Y Yan, X Weng, Patient Quality Assurance Analysis for Tomotherapy. Medical Physics, 32(6), 2005
    
32. X Weng Y Yan, V Ratanatharathorn, J Penagaricano, C Shi L Berkley, E Youssef, N Papanikolaou, Initial experience with a dynamic treatment simulation system. Medical Physics, 32(6), 2005
    
33. Y Yan, X Weng, V Ratanatharathorn, J Penagaricano, C Shi, L Berkley, E Youssef, N Papanikolaou, Treatment simulation for 4D image guided radiation therapy. Medical Physics, 32(6), 2005
    
34. N Papanikolaou, P Mavroidis, C. Kappas, C. Shi, Y Yan, J Penagaricano, Plan evaluation using Biologically Uniform Dose. Radiotherapy and Oncology 76(3), 2005
    
35. N Papanikolaou, H Jiang, C. Shi, Y Yan, The effect of tissue heterogeneity in Tomotherapy planning and delivery. Radiotherapy and Oncology 76(3), 2005
    
36. J. Penagaricano, N. Papanikolaou, Y. Yan, E. Youssef, V. Ratanatharathorn, Feasibility of cranio-spinal axis radiation with the Hi_Art tomotherapy system. Radiotherapy and Oncology 76(1), 2005 pp 72-78
    
37. J. Penagaricano, N. Papanikolaou, E. Youssef , C. Wu, Y. Yan, , V. Ratanatharathorn, Intensity-modulated radiation therapy (IMRT) enabling technologies. J Ark Med Soc. 2005 Oct;102(4):114-7
    
38. S. Stathakis, C Kappas, K Theodorou, N Papanikolaou, JC Rosenwald. An inhomogeneity correction algorithm for irregular fields of high-energy photon beams based on Clarkson integration and the 3D beam subtraction method. J Appl Clin Med Phys. 2006 Winter;7(1):1-13.
    
39. C Shi, N Papanikolaou, Y Yan, X Weng, H Jiang, Analysis of the sources of uncertainty for EDR2 film-based IMRT quality assurance. J Appl Clin Med Phys. 2006 Spring;7(2):1-8.
    
40. M. Fuss, N. Papanikolaou, I. Diaz, CE Thomas, Tomotherapeutic IMRT for rectal and anal cancer, Radiotherapy and Oncology 77(3), 2006
    
41. M. Fuss, N. Papanikolaou, Mega-voltage CT guided Stereotactic Body Radiation Therapy, Radiotherapy and Oncology 77(3), 2006
    
42. P Mavroidis. C Ferreira, S.Shi, J Penagaricano, L Lind, N. Papanikolaou, Comparison of Dose Distributions from Tomotherapy and IMRT treatment plans using Biologically Effective Dose, Radiotherapy and Oncology 77(3), 2006
    
43. P Rassiah, BJ Salter, D Fuller, M Blough, N Papanikolaou, M Fuss, Monte Carlo chracterization of Target Doses in Stereotactic Body Radiation Therapy (SBRT), Acta Oncol. 2006, 45(7), 989-994
    
44. M. Fuss, C. Shi, N. Papanikolaou, Tomotherapeutic stereotactic body radiation therapy:techniques and comparison between modalities, Acta Oncol. 2006, 45(7), 953-960
    
45. Joyner M, Salter BJ, N. Papanikolaou, M. Fuss, Stereotactic body radiation therapy for centrally located lung lesions, Acta Oncol. 2006, 45(7), 802-807
    
46. P Mavroidis. C Ferreira, N. Papanikolaou, Svensson, C. Kappas, B. Lind, A. Brahme, Assessing the difference between planned and delivered intensity-modulated radiotherapy dose distributions based on radiobiological measures. Clin Oncol (R Coll Radiol). 2006 Sep;18(7):529-38
    

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