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Geoffrey Clarke

From Radiological Sciences

Contents 1 Geoffrey D. Clarke 1.1 Academic Appointments 1.2 Other Appointments 1.3 Role in Graduate Program 1.3.1 Committees 1.3.2 Course Instructor 1.3.3 Graduate Students Supervised 1.3.4 Students Supervising 1.4 Education 1.5 Continuing Education 1.6 Certifications 1.7 Clinical Responsibilities 1.8 Research Interests 1.9 Intra- and Extra-mural Support 1.10 Teaching 1.10.1 Spring Semester 2007 1.10.2 Fall semester 2006 1.10.3 Spring semester 2006 1.10.4 Fall semester 2005 1.10.5 Spring semester 2005 1.10.6 Fall semester 2004 1.11 Selected Publications

[edit] Geoffrey D. Clarke

[edit] Academic Appointments

2006 – present	Professor & Vice-Chair of Education	Radiology Department	Education Division	University of Texas Health Science Center at San Antonio, Texas
1999-2006	Associate Professor	Radiology Department	Radiological Sciences Division	University of Texas Health Science Center at San Antonio, Texas
1998-1999	Associate Professor	Radiology Department	Medical Physics Division	University of Texas Southwestern Medical Center at Dallas, Texas
1991-1998	Assistant Professor	Radiology Department	Medical Physics Division	University of Texas Southwestern Medical Center at Dallas
1984-1988	Assistant Professor	Radiology Department	Medical Physics Division	Medical College of Virginia, Virginia Commonwealth University

[edit] Other Appointments

1988-1991	Sr. Medical Physicist	Diagnostic Radiology Parkland Memorial Hospital	Dallas, TX
1979-1980	Field Engineer	Schlumberger Well Services	Carthage, TX

[edit] Role in Graduate Program

Program Director (2006 - present)

[edit] Committees

• Chair of COGS (2005 - present)
• Chair, Recruiting Committee
• Member, Diagnostic Imaging Physics Curriculum Committee
• Member, Mexico Medical Physics Committee

[edit] Course Instructor

• RADI 5011: Radiation & Nuclear Physics (CO-DIRECTOR)
• RADI 6050: Magnetic Resonance Imaging (DIRECTOR)

[edit] Graduate Students Supervised

• Hua Hsuan Chen, Ph.D. Radiological Sciences, UTHSCSA, 2006
• Jason Shirah, M.S. Radiological Sciences, UTHSC San Antonio, 2006
• Chun Ruan, Ph.D. Radiological Sciences, UTHSCSA, 2005
• Bahadir Ozus, Ph.D., Radiological Sciences, UTHSCSA, 2003
• Napapong Pongnapang, Radiological Sciences, UTHSCSA, 2002
• Alex Krimkevich, Ph.D. Radiological Sciences, UTSWMC Dallas, 1997
• Timothy Blackburn, Ph.D. Radiological Sciences, UTSWMC Dallas, 1996
• Mustapha Hatab, Ph.D. Radiological Sciences, UTSWMC Dallas, 1995
• Hong Fang Li, Ph.D. Biomedical Engineering, UTSWMC Dallas, 1994

[edit] Students Supervising

• Nima Kasraie
• Andrew Bresnen
• Yong-Sook Lee
• Daniel Vargas

[edit] Education

11/1984	Ph.D.	Radiological Sciences	University of Texas Health Science Center	Dallas, TX
8/1979	M.S.	Medical Physics	University of Texas Health Science Center at Dallas	University of Texas at Arlington
8/1979	B.A.	Russian Language	University of Texas at Arlington	Arlington, Texas
5/1977	B.A.	Physics & Psychology	North Texas State University	Denton, TX

[edit] Continuing Education

• 48th AAPM Annual Meeting Orlando, FL 7/31-8/1/2006 4.5 credits
• RSNA 2006, 92nd Scientific Annual Mtg. Chicago, IL 11/27-11/29/07 6.5 credits
• SW-AAPM: Physical Methods for Image Guided Interventions and Interventional Radiology, Queretaro, MX 4/16-4/18/2007 12 credits
• MTMI Hands On MRI Workshop for Physicists,Houston, TX 4/21-4/22/2007 22 credits

[edit] Certifications

• American Board of Radiology, Certificate in Diagnostic Radiological Physics, 1991
• American Board of Medical Physics, Certificate in Magnetic Resonance Imaging Physics, 1998.

[edit] Clinical Responsibilities

MRI Physics and Medical Nuclear Physics, University Hospital, San Antonio

[edit] Research Interests

• Cardiovascular Imaging Physics
• Magnetic Resonance Imaging of:
  • coronary flow and flow reserve
  • regional myocardial blood volume
  • myocardial perfusion
  • vascular imaging agents
• Clinical Imaging Equipment Quality Control
• Radiation Safety in Diagnostic Radiology
  • Reference Values for Patient Doses in Diagnostic Radiology
  • Patient Doses in CT Imaging
  • Methods for estimating dose for x-ray angiographic and cardiological imaging equipment.
• In-vivo Magnetic Resonance Spectroscopy
  • P-31 myocardial MRS
  • H-1 & P-31 brain MRS
• Novel MRI Methods
  • multiple quantum coherence imaging
  • parallel MRI

[edit] Intra- and Extra-mural Support

• Source: National Institutes of Health (NIBIB)
• Title: “Enhanced Vascular Imaging Agents” (R21)
• Period: FY 2005-06
• Total: $436,896/275,000 (UTHSCSA contract: $15,000 /$40,000 – 10% effort )
• Role: Co-Investigator (PI: Henry Oviatt, Univ. California at Irvine)
• Grant Detail: The objective of this proposal is to develop a new class of contrast agents for MR imaging the blood pool.

• Source: National Institutes of Health (NCR)
• Title: 3T MRI for San Antonio
• Period: FY 2002-03
• Total Costs: $1,600,000
• Role: Co-Investigator (PI: Jia-Hong Gao)
• Grant Detail: The purpose is to facilitate purchase of a 3.0 Tesla magnet for the Research Imaging Center at UTHSCSA.

• Source: American Heart Association
• Title: Functional assessment of coronary artery disease using high-speed MRI.
• Period: FY 1996-2001 (UT Southwestern, Dallas / UTHSCSA)
• Direct Costs: $299,050 over five years
• Role: Principal Investigator
• Grant Detail: The major goal of this study was to investigate the applicability of echo-planar MRI for obtaining clinically relevant physiological data on coronary flow and myocardial perfusion and function.

• Source: American Heart Association
• Role: Principal investigator
• Title: Flow- function relationships in myocardial ischemia measured using echo-planar magnetic resonance imaging.
• Period: FY95-96; FY 96-97 (UT Southwestern, Dallas)
• Direct Costs: $42,000; $30,690
• Grant Detail: Project to evaluate the effectiveness of high-speed MRI for measuring blood flow and myocardial function in a canine model of acute coronary disease.

• Source: American Heart Association, Texas Affiliate
• Role: Principal investigator
• Title: “Noninvasive assessment of epicardial coronary artery flow by NMR imaging”.
• Period: FY 92-93; FY 93-94 (UT Southwestern, Dallas)
• Direct Costs: $35,096; $35,031
• Grant Detail: Evaluate accuracy of MRI measurements of absolute coronary blood flow and coronary perfusion reserve in a canine model of partial coronary occlusion.

• Source: Picker International, Inc.
• Title: “High Speed MRI”
• Period: 1991-1993 (UT Southwestern, Dallas)
• Direct Costs: $60,000
• Role: Co-Principal Investigator (with R. Peshock, MD)
• Grant Detail: Evaluate the clinical utility of a gradient insert designed to be used for cardiac MRI.

[edit] Teaching

• (past 3 years)
  

[edit] Spring Semester 2007

• RADI 6024 – Radiological Anatomy & Physiology (1 contact hour)

[edit] Fall semester 2006

• RADI 6050 – Magnetic Resonance Imaging COURSE DIRECTOR
• RADI 5011 – Radiation & Nuclear Physics - COURSE CO-DIRECTOR

[edit] Spring semester 2006

• RADI 6049 – Introduction to MRI COURSE CO-DIRECTOR

[edit] Fall semester 2005

• RADI 5011 – Radiation & Nuclear Physics - COURSE DIRECTOR
• RADI 5015 – Intro. Diagnostic Radiological Physics - COURSE DIRECTOR

[edit] Spring semester 2005

• RADI 6024 – Radiological Anatomy & Physiology (3 contact hours)
• RADI 6049 – Introduction to MRI - COURSE DIRECTOR

[edit] Fall semester 2004

• RADI 5011 – Radiation & Nuclear Physics - COURSE DIRECTOR
• RADI 5015 – Intro. Diagnostic Radiological Physics - COURSE DIRECTOR
• RADI 6071 – Supervised Teaching

[edit] Selected Publications

• (last 12 of 33 peer-reviewed articles)

1. Ruan C, Yang SH, PhD, Cusi K, Gao F, CLARKE GD. Contrast-enhanced First-pass Myocardial Perfusion MR Imaging with Parallel Acquisition at 3T. Invest Radiol. 2007 Jun;42(6):352-360.
2. Chen H-H, Boykin RD, CLARKE GD, Gao J-H, Roby JW III. Routine Testing of Magnetic Field Homogeneity on Clinical MRI Systems. Medical Physics, 2006, 33(11): 4299-4306.
3. Ruan C, Yang S, CLARKE GD, Amurao MR, Partyka SR, Bradley YC, Cusi K. First-pass Contrast-enhanced Myocardial Perfusion MRI using a Maximum Up-slope Parametric Map. IEEE Trans Information Technology Biomedicine 2006; 10(3):574-580.
4. Malik JA, Rubal BJ, CLARKE GD, Dick EJ, Ward JA, Harris RA. "Use and Limitations of Magnetic Resonance Phase-Contrast Assessment of Coronary Flow Reserve in a Model of Collateral Dependence" Comparative Medicine 2005 55(4): 317-325.
5. Ozus B, Dodd SJ, CLARKE GD, Fullerton GD. Orientational Dependence of Intermolecular Double Quantum Coherence (iDQC) Signal From Tendon. Magnetic Resonance in Medicine, 2005; 53(5): 1183-1186.
6. Drost D.J., Riddle W., CLARKE G.D. Proton magnetic resonance spectroscopy in the brain: Report of AAPM MR task group #9. Medical Physics 2002; 29: 2177-2197.
7. Price RR, Allison J, Massoth RJ, CLARKE GD, Drost DJ. Practical aspects of functional MRI (NMR Task Group #8). Medical Physics 2002; 29: 1892-1912.
8. Anderson JA, Wang J, CLARKE GD. Choice of phantom material and test protocols to determine radiation exposure rates for fluoroscopy. Radiographics 2000; 20: 1033-1042.
9. Hundley WG, Hillis LD, Hamilton CA, Applegate RJ, Herrington DM, CLARKE GD, Braden GA, Thomas MS, Lange RA, Peshock RM, Link KM. Assessment of coronary arterial restenosis with phase contrast magnetic resonance measurements of coronary flow reserve. Circulation 2000; 101: 2375-2381.
10. Hundley WG, Hamilton CA, CLARKE GD, Hillis LD, Herrington DM, Lange RA, Applegate RJ, Thomas MA, Payne J, Link KM, Peshock RM. Visualization and functional assessment of proximal and middle left anterior descending coronary stenoses in humans with magnetic resonance imaging. Circulation 1999, 99: 3248-3254.
11. Hansen J., Sayad D., Thomas G.D., CLARKE G.D., Peshock R.M. and Victor R.G. Exercise-Induced Attenuation of Alpha-Adrenoreceptor Mediated Vasoconstriction in Humans: Evidence from Phase-Contrast MRI. Cardiovascular Research 1999, 41: 220-228.
12. Al-Omari F., Chwialkowski M., CLARKE G.D., Peshock R.M. An optimized magnetic tissue tagging sequence for echo-planar imaging. Proceedings 11th IEEE Symposium on Computer-Based Medical Systems. IEEE Computer Society 1998, pp. 144-150.

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