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Beth Goins

From Radiological Sciences

Contents 1 Biographical Sketch – Beth A. Goins, Ph.D. 1.1 Academic Appointments: 1.2 Role in Graduate Program: 1.3 Committees: 1.4 Course Instructor: 1.5 Faculty Advisor 1.5.1 Graduates Supervised 1.5.2 Students Supervising 1.6 Education 1.7 Post Graduate Training 1.8 Research Interests 1.9 Inter- and Extra-mural Support 1.10 Teaching: (past 3 years) 1.10.1 Classroom/Laboratory 1.11 Research Summary 1.12 Selected Publications

[edit] Biographical Sketch – Beth A. Goins, Ph.D.

[edit] Academic Appointments:

Associate Professor, Department of Radiology, UTHSCSA

[edit] Role in Graduate Program:

Core Faculty

[edit] Committees:

• Chair, Application Review Committee
• Committee on Graduate Studies (COGS)
• Member, Radiation Biology Curriculum Committee
• Graduate School Awards Committee

[edit] Course Instructor:

• Co-Director RADI 5090 Radiological Sciences Seminar
• Director RADI 5010 Medical Biophysics

[edit] Faculty Advisor

[edit] Graduates Supervised

• Luis A. Medina, Ph.D.
• Cristina Zavaleta, Ph.D.

[edit] Students Supervising

• Anuradha Soundararajan
• Richard Tabassi

[edit] Education

• 1980; BS Chemistry, King College, Bristol, TN
• 1985; MS Biochemistry, University of Tennessee, Knoxville, TN
• 1988; Ph.D. Biochemistry, University of Tennessee, Knoxville, TN

[edit] Post Graduate Training

1988-1991; Biochemistry/Biophysics; National Research Council Postdoc Fellow; Naval Research Laboratory, Washington, D.C.

[edit] Research Interests

• Molecular Imaging
• Small Animal Imaging
• Radiopharmaceutical Development
• Liposomes
• Nanotechnology
• Drug Delivery

[edit] Inter- and Extra-mural Support

Grant No.	PI	Dates	Source	Title	Role
PR043358	(Vail)	1/01/2005-12/31/2007	DOD PRMRP	Targeted Therapies for Myeloma and Metastatic Bone Disease	Co-Investigator (Subcontract PI)
5P30CA054174	(Slaga)	9/1/2005-12/31/2007	Radiofrequency Ablation and Rhenium Liposomes for Solid Tumor Therapy	Co-Investigator
ARP 003659-0025	(Oyajobi)	05/15/2006-05/14/2008	Texas Higher Education Coordinating Board	MicroSPECT/CT Imaging of Cancer-Induced Osteoblast Dysfunction	Co-Investigator
1 R21 EB005187-01A1	(Awasthi)	8/01/2006-7/31/2008	NIH/NIBIB	PET Evaluation of Hemorrhagic Shock and Resuscitation	Subcontract PI
P01 AG 019316-05	(Herman)	12/01/2006-11/30/2011	National Aging Institute (NIH)	Aging, Oxidative Stress and Cell Death (Small Animal Core)	Co-Investigator

[edit] Teaching: (past 3 years)

[edit] Classroom/Laboratory

Date	Course	Title	Credits	Hours
F	2004	RADI 5090	Radiological Sciences Seminar	1	16
S	2005	RADI 5090	Radiological Sciences Seminar	1	16
S	2005	RADI 5010	Medical Biophysics	3	48
F	2005	RADI 5090	Radiological Sciences Seminar	1	16
S	2006	RADI 5090	Radiological Sciences Seminar	1	16
F	2006	RADI 5090	Radiological Sciences Seminar	1	16
S	2007	RADI 5090	Radiological Sciences Seminar	1	16
S	2007	RADI 5010	Medical Biophysics	3	48

[edit] Research Summary

Research interests are mainly in using imaging technology to characterize drug delivery of lipid nanoparticles (liposomes) in various disease models. This research is pre-clinical development of liposome-based drugs so small animal imaging methods and instrumentation (microSPECT. microPET, microCT, ultrasound) are also of interest.

[edit] Selected Publications

• Phillips WT, Lemen L, Goins B, Rudolph AS, Klipper R, Fresne D, Jerabek, PA, Emch ME, Martin C, Fox PT, McMahan CA. Use of Oxygen-15 to Measure Oxygen-Carrying Capacity of Blood Substitutes In Vivo. Am J Physiol 272:H2492-H2499, 1997.
  
• Goins BA, Phillips WT. The Use of Scintigraphic Imaging as a Tool in the Development of Liposome Formulations. Prog Lipid Res, 40:95-123, 2001.
  
• Phillips WT, Andrews T, Liu H, Klipper R, Landry AJ, Blumhardt R, Goins B. Evaluation of [99mTc] Liposomes as Lymphoscintigraphic Agents: Comparison with [99mTc] Sulfur Colloid and [99mTc] Human Serum Albumin. Nucl Med Biol 28:435-444, 2001.
  
• Phillips WT, Medina LA, Klipper R, Goins B. A Novel Approach for the Increased Delivery of Pharmaceutical Agents to Peritoneum and Associated Lymph Nodes. J Pharmacol Exp Ther. 303: 11-16, 2002.
  
• Bao A, Phillips W, Negrete G, Klipper R, Goins B. 99mTc/186Re/188Re-Liposome Radiolabeling for Nuclear Imaging and Targeted Radionuclide Therapy. In: Technetium, Rhenium and Other Metals in Chemistry and Nuclear Medicine 6. M Nicolini and U Mazzi (eds) SGE Editoriali, Italy, pp. 381-386, 2002.
  
• Goins BA, Phillips WT. Radiolabeled Liposomes for Imaging and Biodistribution Studies In: Liposomes: A Practical Approach. V Weissig, V Torchilin (eds) Oxford University Press, Oxford, UK. pp. 319-336, 2003.
  
• Bao A, Goins B, Klipper R, Negrete G, Mahindaratne M, Phillips WT. A Novel Liposome Radiolabeling Method Using 99mTc-“SNS/S” Complexes: In Vitro and In Vivo Evaluation. J Pharm Sci 92: 1893-1904, 2003.
  
• Bao A, Goins B, Klipper R, Negrete G, Phillips WT. 186Re-Liposome Labeling Using 186Re-SNS/S Complexes: In Vitro Stability, Imaging and Biodistribution in Rats. J Nucl Med 44: 1992-1999, 2003.
  
• Medina LA, Klipper R, Phillips WT, Goins B. Pharmacokinetics and Biodistribution of [111In]-Avidin and [99mTc]-Biotin-Liposomes Injected in the Pleural Space for the Targeting of Mediastinal Nodes. Nucl Med Biol 31:41-51, 2004.
  
• Bao A, Goins B, Klipper R, Negrete G, Phillips WT. Direct 99mTc Labeling of Pegylated Liposomal Doxorubicin (Doxil) for Pharmacokinetic and Non-invasive Imaging Studies. J Pharmacol Exp Ther 308: 419-425, 2004.
  
• Medina LA, Calixto SM, Klipper R, Phillips WT, Goins B. Avidin/Biotin-Liposome System Injected in Pleural Space for Drug Delivery to Mediastinal Lymph Nodes. J Pharm Sci, 93:2595-2608, 2004.
  
• Bao A, Zhao X, Phillips WT, Woolley FR, Otto RA, Goins B, Hevezi JM. Theoretical Study of the Influence of a Heterogeneous Activity Distribution on Intratumoral Absorbed Dose Distribution. Med Phys 32: 200-208, 2005.
  
• Medina LA, Calixto SM, Klipper R, Li Y, Phillips WT, Goins B. Mediastinal node and diaphragmatic targeting after intracavitary injection of avidin/99mTc-blue-biotin-liposome system. J Pharm Sci 95:207-224, 2006.
  
• Bao A, Phillips WT, Goins B, Zheng X, Sabour S, Natarajan M, Woolley RF, Zavaleta C, Otto RA. Potential use of drug carried-liposomes for cancer therapy via direct intratumoral injection. Int J Pharm 316:162-169, 2006.
  
• Bao A, Phillips WT, Goins B, McGuff HS, Zheng X, Woolley FR, Natarajan M, Santoyo C, Miller FC,.Otto RA. Setup and characterization of a human head and neck squamous cell carcinoma xenograft model in nude rats. Otolaryngology – Head and neck Surgery 135:853-857, 2006.
  
• Zavaleta C, Phillips WT, Bradley Y, McManus L, Jerabek P, Goins B. Characterization of an intraperitoneal ovarian cancer xenograft model in nude rats using non-invasive microPET imaging. Int J Gynecol Cancer 17: 407-417, 2007.
  
• Medina LA, Goins B, Rodriquez-Villafuerte, M, Bao A, Martinez-Davalos, A, Awasthi V, Galvin OO, Santoyo C, Phillips WT, Brandan ME. Spatial dose distribution in solid tumors from 186Re transported by liposomes using HS radiochromic media. Eur J Nucl Med Mol Imaging 2007 Feb 8 [Epub ahead of print].
  
• Zavaleta CL, Phillips WT, Soundararajan A, Goins BA. Use of avidin/biotin-liposome system for enhanced peritoneal drug delivery in an ovarian cancer model. Int J Pharm (2007) doi:10.1016/j.ijpharm.2007.01.010.

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