Basic Radiation Biology
From Radiological Sciences
Contents |
[edit] Course Title:
Basic Radiation Biology
[edit] Course No.:
RADI 5025
[edit] Instructor:
Mohan Natarajan, Ph.D. and Alonso N. GutiƩrrez, Ph.D.
[edit] Text:
Radiobiology for the Radiologist, E. Hall, 4th Edition, J.B. Lippincott Company, 1994
[edit] Credits:
3
[edit] Semester Offered:
Spring
[edit] Recommended References:
The Blackboard Learning System is used to enhance the didactic course. Information on the subject of the class is posted (including internet links to relevant websites), PDF versions of the Powerpoint files used in the lectures are posted, links to self tests on specific subjects are also posted.
[edit] Evaluation Scheme:
Mid-Term examination; Final examination
[edit] Course Outline:
Overview of the biological effects of ionizing radiation, with attention to the physical, chemical, and biological variables which effect the dose response at the cellular, tissue, and whole body levels. Responses of normal and tumor cells and tissue are examined.
[edit] List of Topics by week
| Week # | Topic |
- Introduction and Overview Course Arrangements
- Physics & Chemistry of Radiation Absorption; Intro to Biology
- Cell Survival Curves; Dose-Response of Normal Tissue
- DNA Strand Breaks & Chromosomal Aberrations; Model Tumor Systems
- EXAMINATION (Intro and Chapters 1-5); Radiosensitivity & Cell Cycle; REVIEW OF FIRST EXAM
- LET & RBE; Repair & Dose Rate Effect
- Oxygen Effect & Reoxygenation; Radioprotectors
- Radiosensitizers & Biored. Drugs; MID-TERM EXAM ; (Intro and Chapters 1-12)
- REVIEW of MID-TERM EXAM
- Cell, Tissue and Tumor Kinetics; Dose & Fractionation
- New Radiation Modalities; Predictive Assays
- Hyperthermia; EXAMINATION (Chapters 12-16)
- Chemotherapeutic Agents; REVIEW of EXAM; Acute Effectes of Total Body Radiation
- Radiation Carcinogensis; Hereditary Effects on Radiation
- Effects on Embryo/Fetus & Cataractogenesis; EXAMINATION (Chapters 17-22)
- Molecular Techniques in Radiobiology; Molecular Events after Ioniz Radiat Exposure
- Diagnostic Radiology & Nuclear Medicine; Radiation Protection
- REVIEW SESSION (including last exam); FINAL EXAM
[edit] Course Appendix:
1 set of exams, 1 student evaluation (1 set of experiment descriptions, etc.)
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